Table 2.
Associations between serum total folate and 5-Methyltetrahydrofolate levels with NAFLD in NHANES 2011–2018.
| Item | NAFLD determined by USFLI | |
|---|---|---|
| OR (95% CI) | value of p | |
| Serum total folate (nmol/L) | ||
| Quartile 1 (≤ 25.30) | Ref. | |
| Quartile 2 (25.30–36.60) | 0.62 (0.49–0.78) | <0.001 |
| Quartile 3 (36.60–54.03) | 0.65 (0.51–0.84) | <0.01 |
| Quartile 4 (>54.03) | 0.43 (0.32–0.56) | <0.001 |
| p for trend | <0.001 | |
| Serum 5-Methyltetrahydrofolate (nmol/L) | ||
| Quartile 1 (≤ 23.38) | Ref. | |
| Quartile 2 (23.38–34.50) | 0.62 (0.48–0.79) | <0.001 |
| Quartile 3 (34.50–51.50) | 0.65 (0.50–0.84) | <0.01 |
| Quartile 4 (>51.50) | 0.41 (0.31–0.55) | <0.001 |
| p for trend | <0.001 | |
NAFLD, non-alcoholic fatty liver disease; USFLI, US fatty liver index.
The following covariates were adjusted: age, sex, race/ethnicity, education level, family economic level, smoking status, drinking status, recreational activity, body mass index, diabetes, hypertension, serum total cholesterol, and total dietary intakes of energy and fat.