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. 2023 Apr 11;14:1126119. doi: 10.3389/fphar.2023.1126119

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Copyright © 2023 Otkur, Liu, Chen, Li, Ling, Lin, Yang, Xia, Qi and Piao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPR35 expression enhanced YAP/TAZ activity. (A,B) Normalized mRNA expression of CTGF and CYR61 in established cell lines relative to parental control cell lines; (C,D) Nuclear and cytoplasmic distribution of YAP and TAZ analyzed by Western blot; (E) The normalized mRNA expression level of GPR35 relative to non-infected 293FT cells; and Normalized mRNA expression of CTGF, CYR61, and ANKRD1; Cells were infected with GPR35 expression lentivirus at the different ratios and harvested for real-time PCR assay after 48 h of incubation. (F) Dual-luciferase reporter assay on TEAD4 luciferase activity relative to Renilla luciferase activity. Cells harvest for the assay after 48 h of incubation with different concentrations of GPR35 expression lentivirus. (G) Normalized mRNA expression level of CTGF and CYR61 relative to shControl cells.