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. 2023 Apr 11;14:1126119. doi: 10.3389/fphar.2023.1126119

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Copyright © 2023 Otkur, Liu, Chen, Li, Ling, Lin, Yang, Xia, Qi and Piao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPR35 knock-down attenuated the inhibitory effect of CID on YAP/TAZ activity. (A) Western blot assay on TAZ expression and YAP phosphorylation in LS174T cells. After 24 h of culture, cells were subject to a fresh medium containing 10% FBS with or without CID for the indicated time. (B) Western blot assay on TAZ expression and YAP phosphorylation in shControl and shGPR35-7 LS174T cells. After 24 h of culture, cells were subject to a fresh medium containing 10% FBS with or without CID for 3 h (C) mRNA expression of CTGF. Cells were harvested for analysis after 12 h of treatment.