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. 2023 Apr 11;14:1126119. doi: 10.3389/fphar.2023.1126119

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Copyright © 2023 Otkur, Liu, Chen, Li, Ling, Lin, Yang, Xia, Qi and Piao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROCK1 kinase inhibitor Y-27632 partly inhibited GPR35-mediated YAP/TAZ activity. 293FT cells were infected with GPR35 expression lentivirus at different ratios of 1:10 for 24 h, and different concentrations of Y-27632 were added directly to the medium. (A) mRNA expression level of YAP/TAZ target genes. (B) The mRNA expression of YAP/TAZ target genes. 293FT cells were infected with different volumes of GPR35 expression lentivirus for 24 h, and 10 μM Y-27632 was added directly to the medium for another 24 h. Then cells were harvested for PCR assay. (C) Western blot assay on YAP and TAZ expression levels, phosphorylation levels, and LATS1 phosphorylation levels.