TABLE 3.
Univariable and multivariable linear regression models to evaluate determinants of care partner outcomes in all amyloid‐positive participants.
| Informal care hours per day (RUD Lite) | Caregiver distress (NPI‐Q) | Depression (GDS) | Quality of Life (EQ‐5D) | Quality of Life (VAS) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | |
| Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | Β (SE) | |
| Patient determinants | ||||||||||
| Age | 0.05 (0.07) | −0.01 (0.10) | 0.05 (0.08) | −0.06 (0.05) | 0.005 (0.03) | 0.03 (0.04) | −0.002 (0.001) | −0.003 (0.002) | −0.29 (0.15) | −0.17 (0.26) |
| Dementia status: dementia | 5.87 (1.11) a | 1.57 (1.35) | 1.18 (0.42) a | 0.61 (0.65) | 7.09 (1.19) a | 0.29 (0.55) | 0.04 (0.02) | 0.03 (0.03) | 0.69 (2.45) | 1.18 (3.34) |
| MMSE | −0.41 (0.10) † | 0.11 (0.12) | −0.53 (0.11) a | 0.10 (0.06) | −0.06 (0.04) | 0.04 (0.05) | −0.003(0.002) | −0.001 (0.003) | −0.15 (0.22) | −0.26 (0.29) |
| CCI | 0.16 (0.40) | −0.19 (0.50) | 0.52 (0.44) | 0.33 (0.24) | −0.04 (0.15) | −0.13 (0.20) | 0.001 (0.008) | 0.01 (0.01) | −0.64 (0.85) | 0.61 (1.22) |
| NPI‐Q severity | 0.47 (0.07) a | 0.22 (0.08) a | 1.25 (0.03) a | 1.22 (0.04) a | 0.15 (0.03) a | 0.12 (0.03) a | −0.001 (0.001) | −0.003 (0.001) | −0.18 (0.16) | −0.19 (0.20) |
| Amsterdam IADL | −0.26 (0.03) a | −0.21 (0.04) a | −0.31 (0.03) † | −0.03 (0.02) | −0.06 (0.01) a | −0.04 (0.02) * | −0.0002 (0.0006) | 0.0001 (0.001) | 0.07 (0.07) | 0.10 (0.11) |
| Care partner determinants | ||||||||||
| Age | 0.12 (0.05) * | 0.06 (0.08) | −0.04 (0.06) | 0.03 (0.04) | −0.006 (0.02) | −0.03 (0.03) | −0.001 (0.001) | −0.002 (0.002) | −0.19 (0.11) | −0.21 (0.19) |
| Sex, female | −0.34 (1.01) | 0.46 (0.96) | 0.70 (1.10) | 0.18 (0.46) | 0.72 (0.37) | 0.68 (0.39) | −0.06 (0.02) a | −0.06 (0.02) a | −4.69 (2.10) * | −5.25 (2.38) * |
| Relation to patient, partner | 4.87 (1.62) a | 4.95 (1.78) a | −1.61 (1.79) | −0.01 (0.85) | 0.80 (0.60) | 1.41 (0.73) | −0.02 (0.03) | −0.003 (0.04) | −2.63 (3.45) | −0.40 (4.40) |
Significant based on P < 0.05.
Significant based on P < 0.01.
Notes: Data are represented as beta coefficients (SE) and odds ratio (95% CI). Analyses were not corrected for multiple testing.
Abbreviations: CCI, Charlson Comorbidity Index; CI, confidence interval; EQ‐5D, the European Quality of Life‐5 Dimensions; GDS, Geriatric Depression Scale; IADL, Instrumental Activities of Daily Living; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; NPI‐Q, Neuropsychiatric Inventory Questionnaire; RUD, Resource Utilization in Dementia; SCD, subjective cognitive decline; SE, standard error; VAS, Visual Analogue Scale.