Table 2.
Univariate and Multivariate Analyses of Prognostic Factors for OS
| Characteristics | Univariate Analysis | P value | Multivariate Analysis | P value |
|---|---|---|---|---|
| Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |||
| Age yr≥65 | 0.813 (0.612-1.082) | 0.156 | ||
| Gender | ||||
| Male, female | 1.211 (0.850-1.727) | 0.289 | ||
| Sarcopenia | 1.859 (1.426-2.423) | <0.001 | 1.612 (1.212-2.143) | 0.005 |
| NLR≥4.0 | 1.700 (1.316-2.196) | <0.001 | 1.205 (1.102-1.379) | <0.001 |
| AFP≥200ng/mL | 1.477 (1.146-1.904) | 0.003 | 1.224 (1.222-1.626) | <0.001 |
| CA19-9≥28U/mL | 0.991 (0.766-1.284) | 0.948 | ||
| CEA≥5mg/L | 1.356 (0.902-2.039) | 0.143 | ||
| ALB<35g/L | 1.384 (1.074-1.783) | 0.012 | 0.980 (0.728-1.319) | 0.892 |
| TBIL≥17.1lmol/L | 1.016 (0.785-1.315) | 0.902 | ||
| AST≥40 IU/L | 1.220 (0.946-1.574) | 0.126 | ||
| ALT≥ 40 IU/L | 1.093 (0.849-1.408) | 0.491 | ||
| ALBI grade | ||||
| 1 | Reference | |||
| 2 | 0.286 (0.168-0.487) | <0.001 | 0.303 (0.176-0.522) | <0.001 |
| 3 | 0.453 (0.297-0.690) | <0.001 | 0.320 (0.205-0.498) | <0.001 |
| BCLC stage | ||||
| A | Reference | |||
| B | 1.319 (0.952-1.828) | 0.096 | 3.955 (0.941-16.626) | 0.061 |
| C | 0.651 (0.482-0.878) | 0.005 | 0.924 (0.584-1.464) | 0.738 |
| Child–Pugh Class | ||||
| A | Reference | |||
| B | 0.003 (0.000-0.046) | <0.001 | 0.305 (0.200-0.479) | 0.201 |
| Tumor size ≥5cm | 1.701 (1.308-2.213) | <0.001 | 1.589 (1.147-2.201) | <0.001 |
| Tumor number ≥2 | 1.501 (1.161-1.941) | 0.002 | 1.777 (1.177-2.685) | 0.003 |
| Portal vein thrombus | 1.675 (1.253-2.239) | <0.001 | 0.362 (0.085-1.538) | 0.168 |
| Cirrhosis | 0.969 (0.751-1.250) | 0.806 | ||
| HBV | 0.853 (0.647-1.123) | 0.257 | ||
| HCV | 0.782 (0.368-1.662) | 0.523 | ||
| Portal hypertension | 0.721 (0.468-1.110) | 0.137 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; ALB, serum albumin; NLR, neutrophil-to-lymphocyte ratio; AFP, alpha fetoprotein; CEA, carcinoembryonic antigen; CA 19-9, Carbohydrate Antigen 19-9; ALBI, albumin-bilirubin; BCLC, Barcelona Clinic Liver Cancer; HBV, hepatitis B virus; HCV, hepatitis C virus; CI, confidence interval.