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. 2023 Mar 15;18(4):861–874. doi: 10.1021/acschembio.2c00958

Table 1. Biosynthetic Gene Clusters Detected in the Genome of Streptomyces ID71268 by antiSMASH and Their Correspondence to Observed Metabolites.

region type class start nt end nt most similar known cluster similarity (%) matched observed metabolites
region 1 T1PKS polyketide:modular type I 134,524 321,356 nigericin 100 nigericin
region 2 NRPS NRP 451,427 529,430 dechlorocuracomycin 8  
region 3 NRPS NRP 645,278 735,666 atratumycin 10 megalochelin
region 4 PKS-like, butyrolactone polyketide 807,668 844,635 chalcomycin A 4  
region 5 redox-cofactor polyketide 900,812 923,143 borrelidin 5 streptochlorin
region 6 butyrolactone   1,166,593 1,177,591      
region 7 siderophore   1,351,073 1,363,598      
region 8 T1PKS polyketide 1,415,846 1,552,737 niphimycins C-E 41 azalomycins
region 9 RiPP-like   1,611,483 1,620,405      
region 10 RiPP-like   1,699,658 1,711,286      
region 11 siderophore NRP 1,934,050 1,949,307 ficellomycin 3  
region 12 other, CDPS NRP 2,274,950 2,317,086 BD-12 14  
region 13 T1PKS polyketide 2,450,052 2,549,639 griseochelin 84  
region 14 terpene terpene + polyketide:type III 2,568,290 2,588,015 merochlorin A/merochlorin B/deschloro-merochlorin A/deschloro-merochlorin B/isochloro-merochlorin B/dichloro-merochlorin B/merochlorin D/merochlorin C 7  
region 15 NRPS-like NRP 2,631,275 2,671,249 echoside A/echoside B/echoside C/echoside D/echoside E 76  
region 16 terpene terpene 2,907,252 2,927,188 xiamycin A 13  
region 17 terpene terpene 3,608,209 3,629,393 geosmin 100  
region 18 arylpolyene polyketide:iterative type I + polyketide:enediyne type I 4,572,658 4,613,875 kedarcidin 7 serpentene
region 19 CDPS, terpene   4,828,266 4,849,580      
region 20 NRPS NRP:glycopeptide + saccharide:hybrid/tailoring 5,523,300 5,566,599 A40926 9  
region 21 ladderane alkaloid 5,767,976 5,809,181 marinacarboline A/marinacarboline B/marinacarboline C/marinacarboline D 23  
region 22 NRPS NRP 5,828,584 5,874,466 atratumycin 10  
region 23 terpene   6,315,096 6,335,429      
region 24 NRPS NRP 6,442,687 6,485,070 diisonitrile antibiotic SF2768 66 diisonitrile antibiotic SF2768
region 25 ectoine other 6,813,891 6,824,334 ectoine 100 ectoine
region 26 NRPS NRP 6,984,391 7,028,025 paenibactin 83 DHB for megalochelin formation
region 27 NRPS, NAPAA NRP:cyclic depsipeptide 7,195,934 7,237,870 stenothricin 13  
region 28 terpene terpene 7,335,572 7,360,024 hopene 61  
region 29 PKS-like, trans-AT-PKS, T1PKS, terpene polyketide 7,489,570 7,686,752 piericidin A1 100 29a: marinomycins, 29b: piericidin
region 30 NRPS, NRPS-like other 7,913,092 7,956,862 spiroindimicin A/spiroindimicin B/spiroindimicin C/spiroindimicin D/indimicin A/indimicin B/indimicin C/indimicin D/indimicin E/lynamicin A/lynamicin D/lynamicin F/lynamicin G 9  
region 31 NRPS   8,043,210 8,091,630      
region 32 terpene   8,272,765 8,293,829