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. 2023 Apr 6;13(8):5428–5448. doi: 10.1021/acscatal.3c00591

Scheme 17. Mechanism Proposed by the Group of Wan for the Formation of β-Ester-γ-amino Ketones.

Scheme 17

(A) Radicals are (re)generated by the CoII/CoIII-catalyzed decomposition of tert-butylhydroperoxide to form reactive α-iminoradicals. (B) The carbene radical reacts with the α-iminoradical, followed by styrene and ultimately a Kornblum-DeLaMare rearrangement to form the β-ester-γ-amino ketone product.