TABLE 1.

Selected pairs of clinical group A Streptococcus strains

Pair	Strain	Sexc	Age (yrs)	Sample origin	Clinical symptom(s)	emm genotypea	PFGE patternb	Type of mutation
1	M1-CovS-WT	M	36	Blood culture	NF + STSS	emm1	1-A	Point mutation in covS
	M1-CovS-Y39H	M	7	Throat swab	Pharyngeal carriage	emm1	1-A
2	M11CovS	F	56	Blood culture	Peritonitis + STSS	emm11	11-A3	Frameshift in covS
	M11WT	M	54	Throat swab	Pharyngeal carriage	emm11	11-A3
3	2003-223	M	72	Pus	Ethmoiditis	emm77	77-A	Frameshift in sfbX
	2003-225	F	43	Cutaneous	Soft skin infection	emm77	77-A
4	2009-126	M	75	Blood culture	Bacteremia	emm77		Mutation upstream of sof
	2009-125	M	80	Cutaneous	Impetigo	emm77
5	2007-635	M	47	Blood culture	Bacteremia	emm94		Loss of the com gene
	2007-949	F	85	Cutaneous	Cellulitis	emm94

^aThe emm genotype was determined as previously described (77).

^bPulsed-field gel electrophoresis (PFGE) patterns were determined as previously described (78).

^cM, male; F, female.