TABLE 2.
Nonreplicating Mtb gene expression in freshly excised rabbit caseum and iMtb-induced caseum surrogate
| Category and gene identifier | Gene name | Mean normalized expression value in: |
|
|---|---|---|---|
| Caseum | Caseum surrogate | ||
| Cell wall biosynthesis | |||
| Rv3825c | pks2 | 1.43 | 1.24 |
| Rv2245 | kasA | 1.16 | 1.04 |
| Lipid metabolism | |||
| Rv1169c | lipX | 1.00 | 1.03 |
| Rv3130c | tgs1 | 0.98 | 1.02 |
| Respiration | |||
| Rv0467 | icl1 | 1.33 | 1.14 |
| Rv2194 | qcrC | 1.12 | 1.09 |
| Rv1854c | ndh | 1.01 | 1.03 |
| Rv3145 | nuoA | 1.09 | 1.04 |
| Rv2583c | relA | 1.09 | 1.10 |
| Rv1131 | gltA1/prpC | 1.12 | 1.05 |
| Rv3341 | metA | 1.10 | 1.02 |
| Rv1130 | prpD | 1.20 | 1.05 |
| Transcription | |||
| Rv2710 | sigB | 1.14 | 1.19 |
| Rv3260c | whiB2 | 1.07 | 1.06 |
| Virulence, detoxification, adaptation | |||
| Rv2031c | hspX | 1.05 | 0.98 |
| Rv3499c | mce4A | 1.24 | 1.09 |
| Transporters | |||
| Rv1737c | narK2 | 1.09 | 1.11 |
| Iron storage | |||
| Rv1876 | bfrA | 1.14 | 1.13 |