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. Author manuscript; available in PMC: 2023 Apr 25.
Published in final edited form as: Nat Chem Biol. 2022 Sep 29;19(3):275–283. doi: 10.1038/s41589-022-01149-6

Extended Data Fig. 7 |. Critical role of nitro group of NMT5 suppressing SARS-CoV-2 infection on pseudovirus entry assay.

Extended Data Fig. 7 |

a, Chemical structure of NMT5 metabolite (NMT5-met, lacking the nitro group). b, HeLa-ACE2 cells were incubated in the presence and absence of 5 μM NMT5-met with SARS-CoV-2 Spike (D614) pseudovirus particles. After 48 h, viral transduction efficiency was monitored by luciferase activity. Inhibitory activity was lost in the absence of the nitro group (compare with Fig. 3c, e). Data are mean + s.e.m. by two-tailed Student’s t test. n = 4 biological replicates.