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. 2023 Mar 7;14(2):e00220-23. doi: 10.1128/mbio.00220-23

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FIG 3 — Gavage BCG vaccination induces gut-homing receptors on Ag-specific Th1* cells. (A and B) Ratio of the AUC of BAL TNF⁺ CD4 T cells to blood TNF⁺ CD4 T cells, as shown in Fig. 1C to F, following in vitro restimulation with either PPD (A) or MTB300 (B). (C) Example FACS plots showing CCR6 and CXCR3 staining in BAL CD4 T cells from week 5 postvaccination. Bulk CD4 T cells are shown in black, and red overlay depicts TNF⁺IFNγ⁺ CD4 T cells. (D and E) Graphs showing percentage of BAL TNF⁺IFNγ⁺ CD4 T cells that are CCR6⁺CXCR3⁺ from all time points postvaccination combined into 1 column, following either PPD (D) or MTB300 (E) stimulation. (F) Example histogram of α₄β₇ staining on CCR6⁺CXCR3⁺ BAL and blood CD4 T cells from week 7 postinfection. (G and H) Graphs showing percentage of TNF⁺IFNγ⁺ CD4 T cells that are α₄β₇⁺ following either PPD (G) or MTB300 (H) restimulation. Graphs show multiple time points combined into a single column with a line drawn to identical time points in the second tissue. A paired t test was used for this comparison, whereas an unpaired t test was used to compare identical tissues across vaccination groups. *, P < 0.05; **, P < 0.01; ***, P < 0.001; and ****, P < 0.0001.