FIG 2.

MXRA8 facilitates cellular infiltration in the quadriceps and ankles in mice with RRV disease. WT and MXRA8^−/− mice (n = 7 per group) were infected with RRV at 10⁴ PFU. Quadriceps (A, C, and E) and ankle joints (G, I, and K) were collected at 0, 7, and 10 dpi and processed for H&E staining. Microscopy images shown are representative of n = 7 mice per group. The numbers of infiltrated cells were analyzed using QuPath. (B, D, F, H, J, and L) Dots represent individual animals (n = 7). The data, representative of two independent experiments, are presented as means ± the SEM. ***, P < 0.001 (using a t test with the Mann-Whitney posttest; ns, not significant).