FIG 1.
Inhibition of GlcNAc WTA modification suppresses ΔglmR mutant phenotypes. (A) Representative image of plaques. (B) Plaque sizes of ΔglmR suppressors. Dotted red line indicates ΔglmR level. * denotes significant differences from ΔglmR by one-way ANOVA (P < 0.05). (C) Growth in BHI with 1 mg/mL lysozyme. Graph is representative of greater than 3 biological replicates. (D) C57BL/6 mice were intravenously infected with 1 × 105 bacteria for 48 h, and CFU from spleens (solid) and livers (open) were determined after 48 h. The solid line and dotted line represent the limit of detection for spleen and liver, respectively. Data are representative of two independent experiments. * denotes significant differences by Mann-Whitney test (P < 0.05).