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RIF and CEF MICs of different rpoB mutants
| Mutation (B. subtilis) | E. coli locus | M. tuberculosis locus | RIF MICa (μg/mL) | CEF MICa (μg/mL) |
|---|---|---|---|---|
| WT | 0.125 | 5.12 | ||
| H482Y | H526Y | H445Y | >4 | 0.16 |
| Q469R | Q513R | Q432R | >4 | 10.24 |
| S487L | S531L | S450L | >4 | 20.48 |
| P520L | P562L | P481L | 4 | 20.48 |
Values are shaded in gray to define resistance. Dark gray with bold represents higher resistance. Values in italic font represents increased susceptibility for the drug.
