Inhibitory assessment of the screened compounds 5a and 5b in comparison with cabozantinib against c-Meta.
| Compound no. | c-Met |
|---|---|
| IC50 (mean ± SEM) (nM) | |
| 5a | 4.27 ± 0.31 |
| 5b | 7.95 ± 0.17 |
| Cabozantinib | 5.38 ± 0.52 |
IC50: compound concentration required to inhibit the enzyme activity by 50%, SEM: standard error mean; each value is the mean of three values.