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. 2023 Mar 20;14:1144903. doi: 10.3389/fgene.2023.1144903

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Copyright © 2023 Wu, Jiang, Ding, Tang, Li, Pi, Zhang, Chen, Chen, Zheng and Piao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression levels of CYP450 enzyme in WT group and Nrf2^−/−group. (A) Changes in mRNA levels of CYP450 enzyme. (B) The expression of CYP450 enzyme protein levels was analyzed by WB and quantified by ImageJ analysis. n = 3 per group. (C) Immunohistochemical detection of CYP450 protein expression in four groups and quantitative analysis of the positive area. n = 2 per group. Scale bars are 50 μm, FA, filtered air; PM, fine particulate matter. WT, wild-type mice; KO, Nrf2^−/− mice. Error bars represent mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.