Figure 4.

Binding antibody levels through day 57 specific to Wuhan-Hu-1 SARS-CoV-2 (a) S protein, (b) RBD, or (C) NTD Binding IgG antibody levels by MSD 4-PLEX assay are shown for those participants in the per-protocol immunogenicity population. Boxplots are based on log-transformed values; boxes and horizontal bars denote IQR range and GM, respectively, with whisker end points equal to the values below or above the median at 1.5 times the IQR. Individual results are represented as dots and the dotted lines represent either the LLOQ or ULOQ. Antibody values reported as below the LLOQ were replaced by 0.5 × LLOQ, whereas values greater than the ULOQ were converted to the ULOQ if actual values were unavailable. In panel a, the LLOQ was 23 (log₁₀[LLOQ] = 1.362) and the ULOQ was 14,000,000 (log₁₀[ULOQ] = 7.146). In panel b, the LLOQ was 19 (log₁₀[LLOQ] = 1.279) and the ULOQ was 6,000,000 (log₁₀[ULOQ] = 6.778). In panel c, the LLOQ was 3 (log₁₀[LLOQ] = 0.477) and the ULOQ was 200000 (log₁₀[ULOQ] = 5.301).

Abbreviations: GM, geometric mean; ID₅₀, 50% inhibitory dose; IgG, immunoglobulin G; IQR, interquartile range; LLOQ, lower limit of quantification; mRNA, messenger RNA; MSD, Meso Scale Discovery; NTD, N-terminal domain; RBD, receptor binding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; ULOQ, upper limit of quantification.