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. 2023 Apr 24;61(1):696–709. doi: 10.1080/13880209.2023.2200787

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — SAG reduces A375 cell metastasis by down-regulating the FAK/PI3K/AKT/mTOR signalling pathways. (A-C) Western blotting assays were used to assess the effect of SAG on FAK and p-FAK (Tyr397). (D) The whole cell extract was harvested to detect p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR proteins by Western blot. (E-G) The histogram shows the relative protein expression of p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR in different groups quantified and normalized against β-actin bars, standard deviation (*p < 0.05, **p < 0.01, ***p < 0.001, as compared to the controls).