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. 2023 Apr 23;15(1):2201156. doi: 10.1080/19490976.2023.2201156

Table 1.

Representative risk genes of neurobehavioral disorders and gut microbial changes reported in these patients.

Neurobehavioral Disorders Candidate risk genes Gut microbial changes
 Refs
Positive association/Higher abundance in patients Negative association/Lower abundance in patients
Autism spectrum disorder Negr1;Ptbp2;Cadps;Fezf2;Tmem33;Dcaf4l1;Slc30a9;Bend4;Nudt12;Kcnn2;Mms22l;Pou3f2;Kmt2e;Chd8;Srpk2;C8orf74;Sox7;Shank3;Pinx1;Mroh5;Mark3;Ckb; Trmt61a;Bag5;Apopt1;Klc1;Cntnap2;Xrcc3;Macrod2; Xrn2; Kiz; Nkx2–4; Nkx2–2 family Prevotellaceae;
genus Bacteroides;
genus Clostridium;
genus Faecalibacterium;
genus Phascolarctobacterium;
genus Collinsella;
genus Corynebacterium;
genus Dorea;
genus Lactobacillus 		phylum Bacteroidetes;
family Acidaminococcaceae;
genus Lachnoclostridium, genus Tyzzerella subgroup 4;
genus Flavonifractor;
genus Coprococcus;
genus Bifidobacterium;
genus Alistipes;
genus Bilophila;
genus Dialister;
genus Veillonella 		4–7
Major depressive disorder Ccdc71; Acbrl1; Rp11-3b7.1; Tlr4; Celf4; Fcf1; Fads1; Arel1; Fads2; Ephx2; Chrna7; Ylpm1; Sppl3; Tiaf1; Traf3; Ccdc36; Sorcs3; Klhdc8b; Tmem258; Lamb2; Nlrp3 phylum Actinobacteria;
class Bacilli;
order Enterobacterales;
family Enterobacteriaceae;
family Bifidobacteriaceae;
family Coriobactericaceae;
family Lachnospiraceae;
family Streptococcaceae;
genus Eggerthella;
genus Olsenella;
genus Collinsella;
genus Lactobacillus;
genus Oscillibacter;
genus Blautia;
genus Erysipelotrichaceae incertaesedis;
genus Holdemania;
genus Streptococcus;
genus Desulfovibrio;
genus Paraprevotella 		phylum Bacteroidetes;
family Prevotellaceae;
genus Dialister;
genus Coprococcus;
genus Sutterella;
genus Faecalibacterium;
genus Clostridium cluster XIVa;
genus Coprococcus 		8–10
Bipolar disorder Tmem108; Rhebl1; Nek4; Glt8b1; Mcm3ap; Cacna1; Ank3; Ncan; Scn2a; Pou3f2; Stk4; Add3; Furin; Hapln4; Ac092661.1; Dclk3; Tmem258; Rp5-882c2.2; Gnl3; Lman2l; Pacs1; Lrrc57; Pacsin2; Htr6; Mchr1 Class Betaproteobacteria
genus Bifidobacterium;
genus Oscillibacter;
genus Megasphaera;
genus Enterococcus;
genus Flavonifractor;
genus Streptococcus 		genus Faecalibacterium;
genus Roseburia;
genus Ruminococcus 		5,11–13
Schizophrenia Grin2a; Sp4; Stag1; Fam120a; Bcl11b; Cacna1c; Rere; Foxp1; Myt1l; Slc39a8 phylum Firmicutes;
class Actinobacteria;
order Enterobacteriales;
family Enterobacteriaceae;
genus Haemophilus;
genus Lachnoclostridium;
genus Prevotella;
genus Escherichia;
genus Shigella;
genus Veillonella;
genus Megasphaera 		genus Bifidobacterium;
genus Coprococcus;
genus Ruminococcaceae;
genus Bacteroides;
genus Haemophilus;
genus Streptococcus;
genus Roseburia 		5,10,13,14
Rett syndrome Mecp2 family Bacteroidaceae;
family Erysipelotrichaceae;
genus Escherichia;
genus Clostridium;
genus Sutterella 		family Ruminococcaceae 15,16