Table 1.
Summary of cohort data
| Controls | Alzheimer’s disease | Mixed | Vascular dementia | |||||
|---|---|---|---|---|---|---|---|---|
| N = 100 | N = 75 | N = 31 | N = 20 | |||||
| Age (y) | 84 (78–90) | 80 (76–85) | 88 (84–92) | 83.5 (77.5–89) | ||||
| Sex (F:M) | 47:53 | 37:38 | 22:9 | 10:10 | ||||
| Post-mortem delay (h) | 43 (33–56) | 35 (22–53) | 36 (24–46) | 43 (29–58) | ||||
| Age of dementia onset (y) | — | 73 (66–80) | 79 (73–87) | 79 (71–86) | ||||
| Duration of dementia (y) | — | 7 (3–10) | 8 (5–11) | 4 (2–6) | ||||
| Braak tangle stage | ||||||||
| 0-II | 82 | 0 | 0 | 15 | ||||
| III-IV | 18 | 12 | 11 | 5 | ||||
| V-VI | 0 | 63 | 20 | 0 | ||||
| BP readings (n) | 19 (8–40) | 10 (4–16) | 23 (15–35) | 8 (5–16) | ||||
| Late-life DBP mean (mmHg) | 78 (73–83) | 80 (76–87) | 81 (74–85) | 80 (78–84) | ||||
| Late-life SBP mean (mmHg) | 140 (130–149) | 142 (130–150) | 148 (136–152) | 145 (133–157) | ||||
| Pre-dementia DBP mean (mmHg) | 81 (77–89) | 87 (80–91) | 85 (83–87) | |||||
| N = 32 | N = 26 | N = 5 | ||||||
| Pre-dementia SBP mean (mmHg) | 143 (127–151) | 148 (135–160) | 145 (144–150) | |||||
| N = 32 | N = 26 | N = 5 | ||||||
| Arteriolosclerosis score | Frontal | Parietal | Frontal | Parietal | Frontal | Parietal | Frontal | Parietal |
| 0 | 18 | 24 | 7 | 11 | 1 | 1 | 0 | 0 |
| 1 | 41 | 43 | 38 | 26 | 6 | 5 | 1 | 4 |
| 2 | 30 | 18 | 22 | 21 | 17 | 19 | 9 | 7 |
| 3 | 5 | 3 | 7 | 5 | 7 | 5 | 10 | 8 |
| Cerebral amyloid angiopathy score | Frontal | Parietal | Frontal | Parietal | Frontal | Parietal | Frontal | Parietal |
| 0 | 69 | 62 | 19 | 21 | 13 | 14 | 16 | 14 |
| 1 | 13 | 13 | 22 | 20 | 4 | 6 | 1 | 2 |
| 2 | 13 | 15 | 21 | 22 | 8 | 4 | 3 | 2 |
| 3 | 5 | 5 | 13 | 11 | 6 | 7 | 0 | 0 |
Age, post-mortem delay, BP readings and DBP and SBP means are presented as median and IQR. Arteriolosclerosis scores were not available for n = 6 controls and n = 1 Alzheimer’s disease case (frontal) and n = 12 controls, n = 12 Alzheimer’s disease, n = 1 mixed and n = 1 vascular dementia cases (parietal). Cerebral amyloid angiopathy scores were not available for n = 5 controls, n = 1 Alzheimer’s disease and n = 2 vascular dementia cases (parietal only). Mean late-life DBP and SBP were calculated from all available BP measurements after the age of 65 for every subject. Pre-dementia DBP and SBP means were calculated, where possible, from all available BP measurements between the age of 65 and 5 years prior to dementia diagnosis.
Abbreviations: DBP = diastolic BP; mixed = mixed Alzheimer’s/vascular dementia; SBP = systolic BP.