Table 2.
Baseline lesion and procedural characteristics with available follow-up angiography suitable for Murray law-based quantitative flow ratio (μQFR) analysis after drug-coated balloon (DCB) treatment of in-stent restenosis (ISR).
| Variables | VOCE (n = 20) | Non-VOCE (n = 149) | P |
|---|---|---|---|
| Target vessel: | 0.81 | ||
| RCA | 6 (30.00%) | 57 (38.26%) | |
| LAD | 11 (55.00%) | 70 (46.98%) | |
| LCX | 3 (15.00%) | 22 (14.76%) | |
| Ostial lesion | 2 (10.00%) | 4 (2.68%) | 0.15 |
| Bifurcation lesion | 5 (25.00%) | 47 (31.54%) | 0.55 |
| Restenosis pattern: | 0.41 | ||
| Mehran I | 4 (20.00%) | 50 (33.56%) | |
| Mehran II | 13 (65.00%) | 73 (48.99%) | |
| Mehran III | 3 (15.00%) | 26 (17.45%) | |
| Shenqi DCB | 11 (55.00%) | 78 (52.35%) | 0.82 |
| QCA parameters: | |||
| Lesion length [mm] | 15.67 ± 5.61 | 14.99 ± 8.39 | 0.73 |
| RVD [mm] | 2.37 ± 0.40 | 2.60 ± 0.42 | 0.02 |
| MLD [mm] | 0.74 ± 0.35 | 0.95 ± 0.39 | 0.02 |
| DS [%] | 67.95 ± 12.10 | 63.20 ± 12.53 | 0.11 |
| DS after DCB [%] | 17.58 ± 15.17 | 21.11 ± 10.10 | 0.32 |
| Procedural data: | |||
| Predilation | 20 (100.00%) | 149 (100.00%) | > 0.999 |
| Cutting balloon | 5 (25.00%) | 38 (25.50%) | 0.96 |
| DCB diameter [mm] | 2.87 (2.62–3.50) | 3.00 (2.75–3.50) | 0.48 |
| DCB length [mm] | 20.00 (20.00–25.50) | 20.00 (17.00–26.00) | 0.91 |
| DCB pressure [atm] | 9 (8–9) | 9 (8–10) | 0.60 |
| DCB Inflation time [s] | 60 (60–60) | 60 (60–60) | > 0.999 |
| No. of DCB used > 1 | 1 (5.00%) | 3 (2.01%) | 0.40 |
| μQFR measurements: | |||
| Baseline μQFR | 0.50 (0.37–0.75) | 0.77 (0.63–0.85) | 0.001 |
| Post-procedural μQFR | 0.88 (0.79–0.94) | 0.96 (0.91–0.98) | < 0.001 |
| Post-procedural μQFR ≤ 0.80 | 6 (30.00%) | 6 (4.03%) | < 0.001 |
| μQFR improvement | 0.30 (0.18–0.41) | 0.18 (0.10–0.34) | 0.01 |
| Residual lesion after DCB treatment | 8 (40.00%) | 21 (14.09%) | 0.01 |
| Diameter difference DCB — RVD | 0.61 (0.43–0.82) | 0.43 (0.29–0.59) | 0.004 |
| Length difference DCB — lesion | 6.36 (2.62–9.32) | 7.26 (2.65–11.88) | 0.59 |
Values are expressed as mean ± standard deviation median (25th–75th percentile) or number (%); DS — diameter stenosis; LAD — left coronary artery; LCX — left circumflex coronary artery; MLD — minimum lumen diameter; QCA — quantitative coronary angiography; RCA — right coronary artery; RVD — reference vessel diameter; VOCE — vessel-oriented composite endpoint