Table 1. List of natural mobile colistin resistance (MCR) plasmids and antimicrobial peptides (AMPs) used in this study.
| AMPs | |||
|---|---|---|---|
| Name | Abbreviation | Major cell and tissue sources | |
| LL-37 cathelicidin | LL37 | Epithelial cells of the testis, skin, gastrointestinal tract, respiratory tract, and in leukocytes, such as monocytes, neutrophils, T cells, NK cells, and B cells |
|
| Human beta-defensin-3 | HBD3 | Neutrophils and epithelial surfaces (e.g., skin, oral, mammary, lung, urinary, eccrine ducts, and ocular) | |
| Cecropin P1* | CP1 | Small intestine |
|
| PR39 | PR39 | Mucosa and lymphatic tissue of the respiratory tract | |
| Protegrin 1 | PRO1 | Bone marrow, leukocytes, and neutrophils | |
| Prophenin-1 | PROPH | Bone marrow and leukocytes | |
| PMAP-23 | PMAP23 | Myeloid tissue, bone marrow, and liver | |
| Chicken cathelicidin-2 | CATH2 | Bone marrow, respiratory tract, gastrointestinal tract, normal intact skin, and multiple lymphoid organs |
|
| Fowlicidin 3 | FOW3 | Bone marrow, lung, and spleen | |
| Colistin | COL | - |
|
| MCR plasmids | |||
| Name (type) | Size (bp) | mcr gene | Reference |
| PN16 (IncI2) | 60,488 | mcr-1 | Yang et al., 2017 |
| PN21 (IncI2) | 60,989 | mcr-1 | Yang et al., 2017 |
| PN23 (IncX4) | 33,858 | mcr-1 | Yang et al., 2017 |
| PN42 (IncX4) | 32,995 | mcr-1 | Yang et al., 2017 |
| WJ1 (IncHI2) | 261,119 | mcr-3 | Yin, 2017 |
| 481 (IncP1) | 53,660 | mcr-3 | Wang et al., 2019 |
*
From pig intestinal parasitic nematode.