Fig.3.

Graphical representation of tumor-associated antigens that are currently being utilized in CAR-T cell therapy for a variety of solid tumors. CAR chimeric antigen receptor, CEA carcinoembryonic antigen, MSLN mesothelin, EGFR epidermal growth factor receptor, EGFRvIII epidermal growth factor receptor variant III, HER-2 human epidermal growth factor receptor-2, GPC-3 glypican-3, PSMA prostate-specific membrane antigen, CLDN18.2 claudin, IL13RA2 interleukin 13 receptor alpha 2, PSCA prostate stem cell antigen, TAG-72 tumor-associated glycoprotein-72, FAP fibroblast activating protein, CAIX carbonic anhydrase IX, c-Met c-mesenchymal- epithelial transition factor, FR-α folate receptor alpha, GD2 disialoganglioside, MUC1 mucin-1, MUC16 mucin-16, NKG2D natural killer group 2d, EpCAM epithelial cell adhesion molecule, ROR receptor tyrosine kinase-like orphan receptor, GUCY2C guanylyl cyclase 2C, DCLK1 doublecortin-like kinase 1, AXL AXL receptor tyrosine kinase