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. 2023 Apr 25;13:6761. doi: 10.1038/s41598-023-32153-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TP53-mutant oligodendroglioma, CNS WHO grade 3. (A) The tumor shows fried egg-appearing monotonous rounded cells with fine capillaries. (B) Some tumor cells have eosinophilic cytoplasm, consistent with minigemistocytic and gliofibrillary oligodendrocytes. (C–E) This tumor cells are positive for IDH1 and are retained expression of ATRX, but negative for vimentin. (F) Copy number variation plots obtained from methylation profiles show 1p/19q co-deletions and chromosomes 4, 9, 14, and 18 deletions (1 copy). In addition, FUBP1 (splicing,247-1G>A, VAF 36.8%; splicing 1105-1G>A, 40.99%), TERT promotor mutation (C228T) and MGMT promoter methylation are present (A,G H&E, C ATRX IHC, D vimentin IHC, E CNV plot, under bar size A, C–D 50, B: 25 micrometer).