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. 2023 Apr 25;13:6742. doi: 10.1038/s41598-023-34061-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images of a 77-year-old man with wild-type EGFR lung adenocarcinoma. (a) CT image showing a mass in the right middle lobe. (b) FDG PET and (c) PET/CT fusion images showing intense uptake in the tumor (SUVmax = 17.72, correlation = 0.45, GLNUr = 13.14, RLNU = 312.8, coarseness = 0.017, LZHGE = 6505, and GLNUz = 8.31). CT computed tomography, PET positron emission tomography, FDG ¹⁸F-fluorodeoxyglucose, EGFR epidermal growth factor receptor, SUVmax maximum standardized uptake value, GLNUr gray-level nonuniformity for run, RLNU run length nonuniformity, LZHGE long-zone high gray-level emphasis, GLNUz gray-level nonuniformity for zone.