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. 2023 Apr 25;14:2364. doi: 10.1038/s41467-023-37905-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Significant cellular distribution scoring patterns between immune cells and malignant cells are shown by (A) smoker status, (B) tumor size, and (C) KRAS mutation status for lung adenocarcinoma (n = 142) specimens. D Significant cellular distribution scoring patterns between malignant cells and immune cells are shown by tumor size for lung squamous cell carcinoma (n = 83) specimens. Violin plots showing the median bar value, lower adjacent value and outside points. Kruskal–Wallis test was used in A–D comparisons between groups. Data from 225 samples was used. Graphs were generated using GraphPad Prism v.9.0.0 using the 26 cell phenotypes distribution patterns and the relevant clinicopathologic information using un-adjusted P-values. (Source data is provided as a source data file).