Table 1.

Patterns of cellular distribution according to histologic type (n = 225)

Panel	Phenotype	Pattern of malignant cellsa			P†
		NSCLC	Adenocarcinoma	Squamous cell carcinoma
1	CD3 +	27.96	25.05	38.86	0.942
	CD3 + CD8 +	25.81	24.03	31.92	0.902
	CD3 + PD-1+	16.53	12.17	23.92	0.132
	CD3 + PD-L1 +	20.19	19.45	22.64	0.386
	CD3 + CD8 + PD-1+	3.20	2.89	4.79	0.996
	CD3 + CD8 + PD-L1 +	11.07	10.82	13.02	0.769
	CD68 +	17.50	15.55	21.86	0.334
	CD68 + PD-L1 +	9.33	8.10	9.81	0.889
2	CD3 +	27.30	22.98	37.84	0.933
	CD3 + CD8 +	29.88	27.20	37.36	0.644
	CD3 + CD8 + GZB +	0.36	0.04	0.89	0.372
	CD3 + CD45RO +	35.84	30.14	48.40	0.933
	CD3 + CD8 + CD45RO +	31.10	25.35	41.40	0.294
	CD3 + CD8negFOXP3 +	29.55	26.75	37.41	0.428
	CD3 + CD45RO + FOXP3 +	24.30	8.92	14.80	<0.001
3	CD3 +	29.14	28.38	32.00	0.260
	CD3 + B7-H3 +	26.49	25.31	28.83	0.816
	CD3 + PD-L1 +	30.27	28.75	32.32	0.230
4	CD3 +	21.00	20.33	28.00	0.633
	CD3 + ICOS +	12.00	11.59	14.00	0.647
	CD3 + LAG3 +	22.30	19.03	29.50	0.633
	CD3 + OX40 +	6.35	4.84	9.50	0.232
	CD3 + TIM3 +	4.07	5.22	3.00	0.261
	CD20 +	6.05	4.14	9.00	0.314
	CD20 + ICOS +	4.11	2.15	7.00	0.342
	CD20 + OX40 +	3.00	2.82	3.50	0.954
	CD20 + LAG3 +	10.89	8.95	15.50	0.280
5	CD68 +	19.64	17.31	24.76	0.884
	CD68 + CD11b +	21.84	18.95	26.81	0.365
	CD66b +	3.54	2.13	6.32	0.186
	CD11b + CD66b +	4.00	2.54	8.50	0.720
	CD11b + CD66b + CD33 +	3.00	1.96	6.00	0.113

Note: NSCLC, non-small cell lung cancer. For determining the patterns of distribution, 26 relevant cell phenotypes with densities >2 cell/mm² were considered in the analysis according to NSCLC and histologic types, totalizing 78 results. In addition, the data was used to correlate with clinicopathologic variables.

^aA score of −10 to 10 indicates a mixed pattern, and a score >10 indicates an unmixed pattern.

† P-values indicate comparison between adenocarcinoma and squamous cell carcinoma using Kruskal-Wallis test and un-adjusted P-values.