Fig. 1.

Cortical and subcortical alterations between ALSC9+ and ALSC9- patients. Panel A: vertex-wise analysis showing significant changes in cortical brain thickness (panel A) ALSC9+ patients compared to ALSC9- patients. All results were reported with p < 0.05 corrected for multiple comparisons using Monte Carlo cluster-based simulation. Clusters color-coded in blue indicate significantly decreased cortical thickness in ALSC9+ patient group compared to ALSC9- patient group. Panel B: vertex-wise analysis showing a significant decrease in the shape of subcortical regions in ALSC9+ compared to ALSC9- patients. Results were corrected using p < 0.05 family-wise error (FWE) -corrected threshold. Only significant results are shown. Abbreviations: ALSC9- = amyotrophic lateral sclerosis C9orf72 non mutation carriers; ALSC9+ = amyotrophic lateral sclerosis C9orf72 mutation carriers. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)