Table 2.

Thalamic nuclei: significant statistical differences in volume of thalamic nuclei between ALSC9+ and ALSC9- patients. Abbreviations: ALSC9- = amyotrophic lateral sclerosis C9orf72 non mutation carriers; ALSC9+ = amyotrophic lateral sclerosis C9orf72 mutation carriers; TIV = total intracranial volume; AV = anteroventral; LD = laterodorsal; LP = latero posterior; VA = ventral anterior; VLa = ventral lateral anterior; VLp = ventral lateral posterior; VPL = ventral posterolateral; VM = ventromedial; MD = mediodorsal; LGN = lateral geniculate; MGN = medial geniculate.

		Thalamus - Left side
		AV	LD	LP	VA	VLa	VLp	VPL	VM	Intralaminar	Midline	MD	LGN	MGN	Pulvinar
ALSC9+	Mean	0.008	0.002	0.007	0.028	0.038	0.050	0.056	0.001	0.026	0.001	0.057	0.016	0.008	0.113
	SD	0.001	0.001	0.002	0.003	0.004	0.005	0.007	0.000	0.003	0.000	0.007	0.003	0.001	0.014
ALSC9-	Mean	0.009	0.002	0.008	0.031	0.041	0.054	0.059	0.001	0.028	0.001	0.065	0.018	0.007	0.125
	SD	0.001	0.001	0.001	0.003	0.004	0.006	0.006	0.000	0.003	0.000	0.007	0.003	0.001	0.013
	z score	−2.89	−0.95	−2.27	−3.38	−2.75	−2.84	−2.51	−1.95	−2.25	−2.25	−3.54	−2.19	1.34	−2.97
p-value		0.045	0.511	0.172	0.008	0.059	0.047	0.102	0.203	0.172	0.172	0.005	0.172	1	0.035
		Thalamus - Right side
		AV	LD	LP	VA	VLa	VLp	VPL	VM	Intralaminar	Midline	MD	LGN	MGN	Pulvinar
ALSC9+	Mean	0.009	0.001	0.007	0.029	0.039	0.051	0.054	0.001	0.026	0.001	0.057	0.016	0.008	0.108
	SD	0.001	0.001	0.001	0.004	0.004	0.006	0.007	0.000	0.003	0.000	0.008	0.002	0.001	0.015
ALSC9-	Mean	0.010	0.002	0.008	0.031	0.042	0.054	0.057	0.001	0.028	0.001	0.067	0.017	0.008	0.121
	SD	0.001	0.000	0.001	0.003	0.004	0.005	0.005	0.000	0.003	0.000	0.009	0.002	0.001	0.013
	z score	−2.66	−1.83	−2.86	−2.71	−2.19	−2.08	−1.26	−1.70	−1.64	−2.06	−3.64	−2.45	0.15	−3.50
p-value		0.069	0.237	0.046	0.064	0.172	0.187	0.414	0.267	0.267	0.187	0.004	0.115	1	0.006