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. 2023 Apr 12;13:1098523. doi: 10.3389/fonc.2023.1098523

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Copyright © 2023 Xia, Li, Ren and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of the circRNA-derived neoepitopes discovered in BC, CLL, and GBM. (A) The number of circRNAs in GBM and normal tissues. (B) The genomic location type of circRNAs in GBM. (C) Comparison of the lengths of circRNA-encoded protein and corresponding UniProt protein. (D) The proportion of HLA class I peptide and class II peptide appearing 1, 2, 3 and ≥ 4 times, respectively. (E) Correlations between the number of circRNAs and the HLA class I-binding neoepitope load.