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. 2023 Apr 12;14:1130662. doi: 10.3389/fimmu.2023.1130662

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Copyright © 2023 Sousa, Queiroz, Guimarães, Pantoja, Barros, Epiphanio and Martins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1β secretion by ND-BMDM and D-BMDM with Nigericin priming and LPS stimulation. IL-1β release after (A) 30 minutes with different glucose concentrations. *P<0.05 D-BMDM 5.5Mm+ vs ND-BMDM 5.5mM+. *P<0.05 D-BMDM 25Mm+ vs ND-BMDM 25mM+. (B) 2 hours with different glucose concentrations. #P<0.05 stimulated groups vs non stimulated. (C) 4 hours with different glucose concentrations. (D) 6 hours with different glucose concentrations. #P<0.05 stimulated groups vs non stimulated. (E) 24 hours with different glucose concentrations. *P<0.05 D-BMDM 5.5Mm+ vs ND-BMDM 5.5mM+. *P<0.05 D-BMDM 25Mm+ vs ND-BMDM 25mM+. IL-1β measurement was performed by enzyme-linked immunosorbent assay. Results represent mean ± SEM. N = 7-13. BMDM: Bone-Marrow Derived Macrophages, from diabetic (D-) and non-diabetic (ND-) C57BL/6 mice.