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miR-1246 in high metastatic tumor EVs promotes metastasis by promoting the adhesion of tumor cells and destruction of the EC barrier. A schematic diagram of the study. miR-1246 released from high metastatic tumor cells via EVs is taken up by ECs and induces ICAM-1 expression via STAT3 activation, which promotes tumor cell adhesion to ECs. Furthermore, miR-1246 destroys the EC barrier by suppressing VE-Cadherin expression and promotes the transendothelial migration of tumor cells.
