Table 1.
Lin28 regulates Let7 related and Let7 independent targets in cancer.
| LIN28-Let7 axis | Let7 Independent Way | |
|---|---|---|
| Positive feedback | STAT3 NF-kB C-Myc IL-6 |
Not reported |
| IGF signaling pathway | AKT RAS mTOR C-myc |
IGF2 IGF-1R Insulin Receptor IRS2/4 |
| Cancer Stemness | ALDH1 Nanog OCT4 SOX2 |
|
| Glucose metabolism | PDK1 AKT |
PDH HK1 |
| Epithelial mesenchymal transition | HMGA2 | HMGA1 |
| Cell cycle proteins | cyclinDl/2, CDK6, CDC34, CDC25a |
cyclinA/B/D, CDK1/2/4, CDC2 and CDC20 |
| Protein Synthesis | Raptor Rictor |
Not reported |
| RNA binding proteins | TDP-43, FUS/TLS TIA-1 hnRNP F |
|
| Histone components | Histone H2A Histone H4H Linker histone H1FX |