TABLE 3.
Treatment of cardiovascular diseases by targeting pyroptosis.
| Targets | Inhibitors | NLRP3 related diseases | References |
|---|---|---|---|
| NLRP3 | MCC950 | Atherosclerosis | 192 |
| Myocardial infarction | 193 | ||
| Melatonin | Atherosclerosis | 195 | |
| Myocardial infarction | 196 | ||
| Colchicine | Atherosclerosis | 143 | |
| Sinapic acid | Diabetic atherosclerosis | 149 | |
| Hydroxytyrosol acetate | Atherosclerosis | 197 | |
| Tranilast | Coronary artery disease | 199 | |
| Myocardial fibrosis | 200 | ||
| OLT1177 | Myocardial infarction | 203 | |
| Oridonin | Myocardial infarction | 204 | |
| Caspase‐1 | VX‐765 | Atherosclerosis | 208 |
| Acute myocardial infarction | 158 | ||
| z‐WEHD‐FMK | Diabetic cardiomyopathy | 209 | |
| Atherosclerosis | 210 | ||
| Ac‐YVAD‐CMK | Ischemia/reperfusion injury | 211 | |
| Hypoxia/reoxygenation injury | 212 | ||
| Ac‐YVAD‐CHO | Chronic kidney disease | 213 | |
| GSDMD | Necrosulfonamide | Ischemia/reperfusion injury | 215 |
| Disulfiram | Heart disease | 217 | |
| Dimethyl fumarate | Ischemia/reperfusion injury | 219 |