Table 3.
Results of multiple linear regression analyses that included interaction terms for the association between ginseng intake status and APOE4 status in predicting cognition.
| B | 95% CI | p | |
|---|---|---|---|
| Memory score | |||
| Immediate EMS | |||
| Ginseng intake | 1.066 | −0.008 to 2.141 | 0.052 |
| APOE4 status | 1.385 | −2.438 to 5.208 | 0.475 |
| Ginseng intake × APOE4 status | −1.484 | −3.892 to 0.924 | 0.225 |
| Delayed EMS | |||
| Ginseng intake | 3.144 | 1.538 to 4.749 | <0.001 |
| APOE4 status | 2.327 | −2.586 to 7.240 | 0.351 |
| Ginseng intake × APOE4 status | −2.241 | −3.463 to −1.018 | <0.001 |
| Non-memory score | |||
| NMS | |||
| Ginseng intake | 1.380 | −0.540 to 3.299 | 0.157 |
| APOE4 status | 2.655 | −4.174 to 9.484 | 0.443 |
| Ginseng intake × APOE4 status | −1.948 | −6.249 to 2.352 | 0.372 |
APOE4, apolipoprotein ε4 allele; EMS, episodic memory score; NMS, non-memory score.
To explore the moderating effects of APOE4 status on the associations between ginseng intake status and cognition, i.e., immediate EMS, delayed EMS, and NMS, the multiple linear regression analyses were performed including two-way interaction terms between ginseng intake status and cognition as additional independent variables.