Table 2.

Prediction performance of CancerSig across 15 cancers

	Dataset	miRNA signature	10-CV accuracy	Sensitivity	Specificity	MCC	AUC
1	BLCA	35	84.40 ± 1.27	0.64 ± 0.04	0.93 ± 0.01	0.65 ± 0.02	0.82 ± 0.01
2	BRCA	34	80.38 ± 1.55	0.79 ± 2.7	0.81 ± 2.26	0.60 ± 0.03	0.81 ± 0.02
3	COAD	21	86.67 ± 2.40	0.89 ± 0.02	0.82 ± 0.03	0.73 ± 0.04	0.81 ± 0.02
4	ESCA	22	87.97 ± 2.35	0.93 ± 0.02	0.78 ± 0.06	0.75 ± 0.04	0.78 ± 0.03
5	HNSC	20	85.20 ± 1.4	0.52 ± 0.06	0.95 ± 0.01	0.57 ± 0.05	0.71 ± 0.03
6	KIRC	18	87.14 ± 1.76	0.85 ± 0.02	0.87 ± 0.02	0.75 ± 0.03	0.87 ± 0.01
7	KIRP	12	89.43 ± 2.01	0.96 ± 0.01	0.73 ± 0.06	0.76 ± 0.04	0.87 ± 0.03
8	LIHCC	23	89.56 ± 1.27	0.94 ± 0.01	0.73 ± 0.03	0.71 ± 0.03	0.86 ± 0.02
9	LUAD	29	74.29 ± 1.33	0.80 ± 0.02	0.65 ± 0.03	0.53 ± 0.02	0.7 ± 0.01
10	LUSC	18	79.11 ± 2.28	0.74 ± 0.06	0.81 ± 0.02	0.61 ± 0.03	0.80 ± 0.02
11	SKCM	27	78.71 ± 2.47	0.79 ± 0.03	0.76 ± 0.04	0.60 ± 0.03	0.75 ± 0.02
12	STAD	20	77.03 ± 1.9	0.70 ± 0.03	0.79 ± 0.13	0.58 ± 0.03	0.78 ± 0.03
13	THCA	26	76.37 ± 1.20	0.86 ± 0.02	0.61 ± 0.04	0.55 ± 0.02	0.71 ± 0.01
14	READ	11	94.57 ± 2.8	0.90 ± 0.05	0.97 ± 0.02	0.88 ± 0.05	0.95 ± 0.03
15	UVM	13	93.33 ± 3.5	0.93 ± 0.04	0.90 ± 0.13	0.86 ± 0.06	0.85 ± 0.03
	Mean ± SD	21.93 ± 7.30	84.27 ± 6.31	0.81 ± 0.12	0.80 ± 0.10	0.67 ± 0.11	0.80 ± 0.06

10-CV, 10-fold cross-validations; MCC, Matthews correlation coefficient; AUC, area under the ROC curve; SD, standard deviation.