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. 2023 Apr 12;14:1074242. doi: 10.3389/fimmu.2023.1074242

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Copyright © 2023 Zhao, Gao, Li, Tian, Ma, Sun, Chen, Zhang and Qi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of FADS2 knockdown on the functions of BC cell lines. (A–E) RT-qPCR and Western blotting to detect the expression of FADS2 in MDA-MB-231 and BT474 cells, β-actin acts as control. (B–F) MTS assay was used to detect the effect of FADS2 down-regulation on cell proliferation. (C–G) Transwell cell migration assay to detect the effect of FADS2 down-regulation on cell migration ability. (D–H) Transwell cell invasion assay was used to detect the effect of FADS2 down-regulation on cell invasion ability. (I) Enrichment of EMT signaling pathway with FADS2 expression was shown using enrichment analysis of TCGA. (J) Relative expression levels of FADS2, E-cadherin, N-cadherin and Snail in the MDA-MB-231 cells transfected with Control or siFADS2, GAPDH acts as control. ^ns P > 0.05, ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001.