Table 2.
Correlation analysis between WAS and related genes and markers of immune cells in Tumor Immune Estimation Resource (TIMER2.0).
| Description | Gene markers |
ccRCC None Cor |
p | Purity Cor |
p |
|---|---|---|---|---|---|
| CD8 T cell+ | CD8A | 0.716 | *** | 0.682 | *** |
| CD8B | 0.706 | *** | 0.68 | *** | |
| TBX21 | 0.549 | *** | 0.521 | *** | |
| IFNG | 0.655 | *** | 0.61 | *** | |
| CXCL9 | 0.672 | *** | 0.625 | *** | |
| CXCL10 | 0.592 | *** | 0.54 | *** | |
| T cell (general) | CD3D | 0.793 | *** | 0.769 | *** |
| CD3E | 0.819 | *** | 0.797 | *** | |
| CD3G | 0.723 | *** | 0.696 | *** | |
| CD2 | 0.799 | *** | 0.775 | *** | |
| B cell | CD19 | 0.534 | *** | 0.493 | *** |
| CD79A | 0.578 | *** | 0.537 | *** | |
| BLK | 0.539 | *** | 0.508 | *** | |
| Monocyte | CD86 | 0.786 | *** | 0.763 | *** |
| CD115 (CSF1R) | 0.767 | *** | 0.749 | *** | |
| TAM | CCL2 | 0.18 | *** | 0.112 | * |
| CD68 | 0.493 | *** | 0.497 | *** | |
| IL10 | 0.537 | *** | 0.465 | *** | |
| CSF2 | 0.283 | *** | 0.29 | *** | |
| M1 Macrophage | INOS (NOS2) | 0.078 | 0.0736 | 0.011 | 0.806 |
| IRF5 | 0.476 | *** | 0.468 | *** | |
| COX2(PTGS2) | 0.043 | 0.319 | -0.021 | 0.651 | |
| M2 Macrophage | CD163 | 0.504 | *** | 0.474 | *** |
| VSIG4 | 0.599 | *** | 0.561 | *** | |
| MS4A4A | 0.572 | *** | 0.527 | *** | |
| Neutrophils | CD66b(CEACAM8) | 0.045 | 0.3 | 0.05 | 0.285 |
| CD11b (ITGAM) | 0.674 | *** | 0.644 | *** | |
| CCR7 | 0.62 | *** | 0.584 | *** | |
| Natural killer cell | KIR2DL1 | 0.156 | *** | 0.118 | * |
| KIR2DL3 | 0.2 | *** | 0.203 | *** | |
| KIR2DL4 | 0.409 | *** | 0.392 | *** | |
| KIR3DL1 | 0.181 | *** | 0.198 | *** | |
| KIR3DL2 | 0.287 | *** | 0.281 | *** | |
| KIR3DL3 | 0.153 | *** | 0.129 | ** | |
| KIR2DS4 | 0.176 | *** | 0.16 | *** | |
| Dendritic cell | HLA-DPB1 | 0.809 | *** | 0.809 | *** |
| HLA-DQB1 | 0.527 | *** | 0.49 | *** | |
| HLA-DRA | 0.747 | *** | 0.74 | *** | |
| HLA-DPA1 | 0.735 | *** | 0.709 | *** | |
| BDCA-1(CD1C) | 0.357 | *** | 0.293 | *** | |
| BDCA-4(NRP1) | 0.033 | 0.452 | -0.042 | 0.364 | |
| CD11c (ITGAX) | 0.649 | *** | 0.624 | *** | |
| Th1 | T -bet (TBX21) | 0.549 | *** | 0.521 | *** |
| STAT4 | 0.59 | *** | 0.531 | *** | |
| STAT1 | 0.592 | *** | 0.546 | *** | |
| IFN-γ (IFNG) | 0.655 | *** | 0.61 | *** | |
| TNF-α (TNF) | 0.442 | *** | 0.413 | *** | |
| Th2 | GATA3 | 0.319 | *** | 0.318 | *** |
| STAT6 | 0.117 | ** | 0.139 | ** | |
| STAT5A | 0.666 | *** | 0.633 | *** | |
| IL13 | 0.117 | ** | 0.09 | 0.0538 | |
| Tfh | BCL6 | 0.083 | 0.0565 | 0.081 | 0.0832 |
| IL21 | 0.23 | *** | 0.208 | *** | |
| Th17 | STAT3 | 0.192 | *** | 0.146 | ** |
| IL17A | 0.065 | 0.133 | 0.032 | 0.5 | |
| Treg | FOXP3 | 0.69 | *** | 0.657 | *** |
| CCR8 | 0.605 | *** | 0.561 | *** | |
| STAT5B | 0.056 | 0.199 | 0.052 | 0.262 | |
| TGFβ (TGFB1) | 0.221 | *** | 0.173 | *** | |
| T cell exhaustion | PD-1 (PDCD1) | 0.771 | *** | 0.755 | *** |
| PDL-1(CD274) | 0.227 | *** | 0.198 | *** | |
| CTLA4 | 0.712 | *** | 0.682 | *** | |
| LAG3 | 0.731 | *** | 0.703 | *** | |
| TIM-3 (HAVCR2) | 0.299 | *** | 0.245 | *** | |
| GZMB | 0.516 | *** | 0.468 | *** |
ccRCC, renal clear cell carcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment; Purity; correlation adjusted by purity.
*p < 0.05; **p < 0.01; ***p < 0.001.