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. 2023 Apr 12;11:1133090. doi: 10.3389/fbioe.2023.1133090

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Copyright © 2023 Bao, Wang, Zhou, Yang, He and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The prediction results of our model for some challenging cases of B-Scan. (A) autocorrelation noise; (B) strong reflection noise; (C,D) low contrast and blurred boundaries; (E) different density and morphology of organoid. (F) Well plates. (a1)–(f1) are OCT images, (a2)–(f2) are ground truth, (a3)–(f3) are neural network prediction results, and (a4)–(f4) are fusion results (green) of ground truth (red) and prediction results (blue). The yellow arrows indicate possible problems in the OCT images. The white arrow in row 3 points out that Matrigel was misclassified as an organoid. The blue arrow in row 4 points out that the organoid was not successfully segmented.