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. 2023 Apr 12;11:1133090. doi: 10.3389/fbioe.2023.1133090

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Copyright © 2023 Bao, Wang, Zhou, Yang, He and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shape and size changes of colon cancer organoids during the monitoring period. (A) Colon cancer organoids at different time points. From left to right are 3D OCT images, 3D segmentation results and the top views. Different diameters of organoids are marked with different colors (yellow:50 μm > d ≥ 32μm, green: 90 μm > d ≥ 50μm, red: d ≥ 90 μm). (B–D) Enlarged views of the three organoids marked as 1, 2, and 3 by the yellow boxes in (A). (E) The volume growth analysis of three organoids in (B–D) over 7 days.