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. 2023 Apr 12;11:1140617. doi: 10.3389/fped.2023.1140617

Table 9.

Exemplary step scheme for combining antihypertensive drug classes.

GRADE
Step 1 (Initial therapy) Monotherapy with
  • ACEi or ARB

  • CCB

C
Step 2 Combination Therapy
  • ACEi or ARB + CCB

  • ACEi or ARB + Diuretic

D
Step 3
  • ACEi or ARB + CCB + Diuretic

  • ACEi or ARB + CCB + ß-Blocker

D

ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; Strict contraceptive measures are required for all girls/women of childbearing age who are prescribed RAAS inhibitors!.