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. 2023 Apr 12;14:1108682. doi: 10.3389/fimmu.2023.1108682

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Copyright © 2023 Ayoub, Dauvilliers, Barateau, Vermeulen, Mouton-Barbosa, Marcellin, Gonzalez-de-Peredo, Gross, Saoudi and Liblau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological pathways enriched in the CSF of NT1 patients in both cohort 1 and cohort 2. (A) Scheme of the analytical design: In each cohort separately, total proteins were ranked based on their fold change then pathway analysis was performed using the GSEA feature of Cluster Profiler. Three databases were interrogated (GOBP, KEGG and REACTOME). Only the statistically significant pathways shared between the two cohorts were considered for further analysis. (B–D) Log10 p-values of pathway enrichment in cohort 1 (Orange) and cohort 2 (Purple), in reference to the three databases. Values close to each bar represent the normalized enrichment score (NES), predicting activation or inhibition of a given pathway.