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. 2023 Apr 12;14:1102465. doi: 10.3389/fphar.2023.1102465

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Copyright © 2023 Wagner, Pehar, Yan and Kulka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AME-1 potentiates poly(I:C)-induced production of IL-8. HMC3 were treated with AME-1 (50–5,000 μg/mL) or left untreated for 3 h and stimulated with 1 μg/mL LPS, 0.25 μg/mL TNF, or 0.5 μg/mL poly(I:C) for 24 h. (A, B) AME-1 has no effect on LPS-induced production of IL-8 or IL-6. (C, D) AME-1 potentiates poly(I:C)-induced production of IL-8 but has no effect on IL-6. (E, F) AME-1 has no effect on TNF-induced production of IL-8 or IL-6. Data presented as mean ± SEM for n = 3. Statistical significance was calculated using Two-Way ANOVA with Tukey post hoc analysis: p ≤ 0.0001 (****).