TABLE 1.

Metabolite composition of AME-1 as analyzed by NMR.

	Compound name	Concentration (mM)
1	2-Aminoadipate	0.12949
2	2-Hydroxy-3-methylvalerate	0.12315
3	2-Hydroxybutyrate	0.08419
4	2-Hydroxyglutarate	0.12585
S	2-Hydroxyvalerate	0.04945
6	2-Methylgiutarate	0.03953
7	2-Octenoate	0.11389
8	2-Oxocaproate	0.03706
9	2-0xosilutarate	0.13334
10	2-Phenylpropionate	0.02588
11	3,5-Dibromotyrosine	0.04653
12	3-Aminoisobutyrate	0.06488
13	3-Hydroxy-3-methyiglutarate	0.06143
14	3-Methylgiutarate	0.04506
15	4-Aminobutyrate	0.02188
16	Acetate	0.02562
17	Adenosine	0.01331
18	ADP	0.0351
19	Arabinitol	0.10428
20	Arginine	0.10289
21	Aspartate	0.07789
22	Azelate	0.04827
23	Betaine	0.0201
24	Biotin	0.05926
25	Butyrate	0.04999
26	Carnitine	0.09769
27	cis,cis-Muconate	0.02202
28	Citraconate	0.02804
29	Citrate	0.02914
30	Cytosine	0.02576
31	dTTP	0.02821
32	Formate	0.02408
33	Fucose	0.17544
34	Galactarate	0.03687
35	Glucarate	0.09589
36	Glycerol	0.11244
37	Guanidoacetate	0.48254
38	Guanosine	0.03392
39	Histidine	0.01991
40	Hydroxyacetone	0.04515
41	InosIne	0.01061
42	Isocitrate	0.59453
43	Isoleuclne	0.06338
44	Lactate	0.09885
45	Leucine	0.04843
46	Lysine	0.08915
47	malate	0.02791
48	Malonate	0.02636
49	MethlonIne	0.03011
50	N,N-DImethylformamIde	0.07896
51	N-Acetylcysteine	0.10239
52	Nicotinate	0.03333
53	Ornithine	0.02167
54	Phenylacetate	0.01638
55	PhenylalanIne	0.06351
56	Propylene glycol	0.03872
57	Succinate	0.02113
58	Syringate	0.00713
59	Tartrate	0.12868
60	Taurine	0.16596
61	Trehalose	1.37787
62	Tyrosine	0.03146
63	Uddlne	0.05346
64	Valine	0.08462
65	8-Alanine	0.08225