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. 2023 Apr 12;14:1183052. doi: 10.3389/fphar.2023.1183052

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Copyright © 2023 Gao, Zhang, Xu, Ma, Chen, Chen and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of I13 on the mRNA and protein expression levels of differentiation-related genes in BaF3-T315I cells. (A) Quantitative real-time PCR analysis of mRNA expression level of BCR-ABL. The cells were exposed to 1.1 µM of I13 for 24, 48, or 72 h. (B) Immunoblotting analysis of BCR-ABL, p-BCR-ABL, H3, Ac-H3, H4, and Ac-H4. (C) The bar graph shows the intensity of the protein band quantified by AI600 images. The cells were exposed to 0.275, 0.55, and 1.1 µM of I13 or 1.1 µM of imatinib for 72 h (*p < 0.05, **p < 0.01).