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. 2023 Apr 25;220(7):e20221853. doi: 10.1084/jem.20221853

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© 2023 Stolley et al.

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Figure S4. — Oral T cell reactivation induces minor salivary gland inflammation. (A) VPEP memory mice were orally swabbed with gp33 or SIIN peptide and buccal mucosa was isolated 8 h later. A pronounced increase in OT-I T cells (teal) and pan-leukocytes (red) was observed within minor salivary glands exclusively in SIIN-treated buccal mucosa. Bottom row: Nuclear and E-Cadherin staining removed to better visualize OT-I T cell (CD45.1) and pan-leukocyte (CD45.2) infiltration. (B) Left: Relative abundance of CD103⁺ and CD103^neg OT-I T cells isolated from major salivary glands of VPEP mice receiving a single treatment with IgG-SAP or 103-SAP 1 wk prior. Right: Representative flow cytometry. All dots represent individual mice, with N = 10–11 mice per group from three independent experiments. Numbers above bar graphs represent mean fold change between the relevant comparisons. **, P < 0.01 as determined by an unpaired Student’s t test.