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. 2023 Apr 1;26(4):106561. doi: 10.1016/j.isci.2023.106561

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Molecular changes in the liver of FXR knockout mice with AQP8 overexpression

(A–D) Analysis of mRNA on hepatic lipogenesis, fatty acid oxidation, bile acid metabolism and inflammation-related genes; β-actin was used as an internal control.

(E) Western blot assays analysis of the accumulation of AQP8 and lipogenic genes in the liver tissue samples of the three groups. (p)SREBP-1c, precursors SREBP-1c; (n)SREBP-1c, nuclear SREBP-1c. The data represent the mean ± SEM values, n = 9–11.∗p<0.05 ∗∗p<0.01 ∗∗∗p<0.001.