REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
AQP8	Sigma	RRID:AB_1839763
FAS	Cell Signaling Technology	Cat# cs-3180
Hsp90	Santa Cruz	RRID:AB_675659
SREBP-1c	Thermo Fisher Scientific	RRID:AB_2194231
ChREBP	Thermo Fisher Scientific	RRID:AB_11153460
Bacterial and virus strains
Ad-GFP	Xitubio, Shanghai	N/A
Ad-AQP8	Xitubio, Shanghai	N/A
Ad-shAQP8	Xitubio, Shanghai	N/A
Biological samples
RIPA	BIOCOLOR	Cat# R0095
Trizol Reagent	Life Technologies	Cat# 15596026
PVDF membranes	Millipore	Cat# IPVH00010
NEFA HR color reagent	Wako Life Sciences	Cat# 294-63601
β-hydroxybutyrate Assay kit	Jian cheng, Nanjing, China	Cat# H69
Triglyceride Quantification Kit	Biovision	K622–100
Experimental models: Cell lines
HepG2	ATCC	Cat#HB-8065
Hepatocyte	This paper	N/A
Experimental models: Organisms/strains
Mouse: C57BL/6J	Vital River Laboratories	N/A
Mouse:C57BLKS/J-Leprdb/Leprdb	Model Animal Research Center of Nanjing University	N/A
Mouse: Nr1h4tm1Gonz/J	Jackson Laboratory	RRID: IMSR_JAX:004144
Software and algorithms
GraphPad Prism 8	Graphpad	https://www.graphpad.com/
Other
High fat diet	Diet Research	D12492i