REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD45	Biolegend	Cat# 103105; RRID: AB_312970
F4/80	Biolegend	Cat# 123116; RRID: AB_893481
CD11b	Biolegend	Cat# 101227; RRID: AB_893233
Fcrl5	R&D	Cat# FAB6757G; RRID: AB_2927459
CD11c	Biolegend	Cat# 117318; RRID: AB_493568
MHCII	Biolegend	Cat# 107606; RRID: AB_313321
VEGFR2	Biolegend	Cat# 136413; RRID: AB_2561606
Ly-6a	Santa Cruz	Cat# sc-52601; RRID: AB_630228
F4/80	Santa Cruz	Cat# sc-377009; RRID:AB_2927461
Itgad/Cd11d	Abbexa	Cat# abx101639; RRID: AB_2927460
CD31	Abcam	Cat# ab222783; RRID: AB_2905525
vWF	Santa Cruz	Cat# sc-365712; RRID: AB_10842026
Egr1	Santa Cruz	Cat# sc-101033; RRID: AB_1122474
Chemicals, peptides, and recombinant proteins
High-fat diet	Research Diets	Cat# D12492
Fructose	Sigma-Aldrich	Cat# F0127
Sucrose	Sigma-Aldrich	Cat# V900116
Haematoxylin and Eosin dye	Servicebio	Cat# G1005
Oil Red O dye	Sigma-Aldrich	Cat# 1320-06-5
Picrosirius red dye	Servicebio	Cat# GC307014
TRIzol	Takara	Cat# 9108
SYBR Premix Ex Taq II	Takara	Cat# RR820A
Red blood cell lysate buffer	Miltenyi Biotec	Cat# 130-094-183
DAPI	Yeason	Cat# 40728ES03
Critical commercial assays
Liver Dissociation Kit	Miltenyi Biotec	Cat# 130-105-807
Fixation/Permeabilization Kit	BD Biosciences	Cat# 554722
PrimeScript RT Master Mix Kit	Takara	Cat# RR036A
BD Rhapsody cDNA Kit	BD Biosciences	Cat# 633773
BD Rhapsody Targeted mRNA&AbSeq Amplification Kit	BD Biosciences	Cat# 633801
Deposited data
Raw sequencing data	National Omics Data Encyclopedia	OEP003311
Oligonucleotides
qPCR primers, see Table S1	This paper	N/A
Software and algorithms
FlowJo 10	Treestar	https://www.flowjo.com/solutions/flowjo
Leica software package	Leica	N/A
ImageJ software	NIH	https://imagej.nih.gov/ij/
GraphPad Prism 8	GraphPad Software	https://www.graphpad.com/
R package	R CRAN	http://www.R-project.org/
Seurat	Butler et al., 201862; Stuart et al., 201963	https://satijalab.org/seurat/
SingleR (v1.4.1)	Aran et al., 201964	https://github.com/dviraran/SingleR
Monocle2	Qiu et al., 201765	https://github.com/cole-trapnell-lab/monocle-release
CellphoneDB	Efremova et al., 202066	https://www.cellphonedb.org/